2026-10-24Pembelajaran STEAM Hybrid Berbasis Proyek “Kipas Eco Craft” Dari Tutup Botol Bekas: Studi Kualitatif Di Kelas VI SDN 004 DomoSemantic Scholar · Vovi Tridian Ulfah, J. Alim, Neni Hermita · AL-IMAM: Journal on Islamic Studies, Civilization and Learning SocietiesObjective: This study aims to describe the implementation of Science, Technology, Engineering, Art, and Mathematics (STEAM) learning through a hybrid project-based approach using “Kipas Eco Craft,” a product made from used bottle caps, as well as student engagement, implementatio
2026-10-21Adaptation of fluorescence rescue reporters of mistranslation for use in Saccharomyces cerevisiaebioRxiv · molecular biology · v1Specific mutations to tRNA genes can cause mistranslation - the incorporation of amino acids mismatched to the mRNA code during translation. The effects of mistranslation are hugely varied, depending on the form of mistranslation and various contextual factors. A key aspect of mu
2027 Mar-AprPerineal Urethrostomy After Urethral Stricture: Step-by-Step Surgical Technique.PubMed · Silva RP, Uneda LAM, Vieralves RR et al. · International braz j urol : official journal of the Brazilian Society of UrologyPublished 2027/03/01 00:00. International braz j urol : official journal of the Brazilian Society of Urology
2026-10-21Ubiquitin isopeptidase and esterase activities have distinct catalytic requirementsbioRxiv · biochemistry · v1Post-translational ubiquitin signaling is reversed by dedicated proteases termed deubiquitinases, many of which utilize a cysteine-based catalytic triad to cleave the isopeptide linkage. This activity represents canonical isopeptidase activity that has been mechanistically well c
2026-10-21AutoMod: A Software Tool for High-Accuracy Design of Curved DNA Origami NanostructuresbioRxiv · bioengineering · v1In the design of DNA origami (DO) nanostructures, structural information, such as equilibrium conformation, is encoded by nucleotide sequences. The problem of finding the correct sequences for a certain target conformation is a demanding computational task, commonly addressed wit
2027 Mar-AprRobot-Assisted Radical Prostatectomy in a Post-Enucleation Gland.PubMed · de Carvalho PRS, Viterbo RG, Carrerette FB et al. · International braz j urol : official journal of the Brazilian Society of UrologyPublished 2027/03/01 00:00. International braz j urol : official journal of the Brazilian Society of Urology
2026-10-21Anatomically optimised structural connectome derivation for the neonatal brainmedRxiv · pediatrics · v1Structural connectomics provides a means of characterising white matter (WM) network organisation using diffusion MRI (dMRI), but reconstructing neonatal structural connectomes remains challenging due to the immature and heterogeneous nature of the developing brain. Although rece
2026-10-24Sensitivity Patterns of Different Types of Bacterial OrganismsSemantic Scholar · M. Kamruzzaman, A. al Mamun, Kazi Shafiqul Alam et al. · SAS Journal of SurgeryBackground: Infections of wounds have long been recognized as a leading source of illness, especially in trauma patients, but are becoming further complicated due to antimicrobial resistance. Knowing the microbial flora and its sensitivity to antibiotics is important to guide emp
2026-10-21Accentuated Divergence, Constrained Expression: Autistic Traits Modulate the Creative Brain in Adults with ADHDmedRxiv · psychiatry and clinical psychology · v1Background: Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous neurodevelopmental condition, and co-occurring autistic traits may shape its phenotypic expression. Although creativity has been discussed as a relative strength in ADHD, it remains unclear whether aut
2026-10-21Fibronectin Tethering as a Shear-thinning Bio-Annealing Strategy for Granular HydrogelsbioRxiv · bioengineering · v1Granular hydrogel scaffolds (GHS) are injectable, integrative biomaterials built from hydrogel microparticles that permit rapid cell infiltration independent of scaffold degradation. Microporous annealed particle (MAP) scaffolds, a sub-class of GHS, use inter-microparticle crossl
2026-10-21Clinicians Perspectives on Fighting the VentilatormedRxiv · pediatrics · v1Introduction: Fighting the ventilator (FV) is characterized by a patients active counteraction of respiratory gas flow across multiple breaths during mechanical ventilation. An effective ventilation is prevented during such episodes. The objective of this exploratory study was to
2026-10-21The Muskox Way: Humans, plants and animals in northeast Greenland through the HolocenebioRxiv · ecology · v1The Muskox Way hypothesis suggests that the first humans entering northeast Greenland from Arctic Canada followed and hunted muskox. Yet whether muskox arrived before people remains debated, as only two bones predate the Independence culture (4500-3900 cal BP). More broadly, the
2026-10-21Hexosyl transfer via a covalent intermediate within a dual retaining and inverting enzymebioRxiv · biochemistry · v1Bifunctional glycosyltransferases underpin biosynthesis of essential glycans, including bacterial capsular antigens, and eukaryotic glycosaminoglycans. Typically, these enzymes transfer hexose sugars from activated nucleotide-phosphate donors, forming new glycosidic bonds with ei
2026-10-23Effects of Food Intake on Biomarker Activity in Normal Humans Taking ImmulinaClinical trials · Phase 2 · Not yet recruiting · Sponsor: University of Mississippi Medical Center · Registry update posted 2026-10-23 · Enrollment: 250 · Primary completion: 2030-06-30The need for a generally available product that can safely and effectively increase antiviral resilience in susceptible populations became highly relevant during the recent COVID pandemic. The value continues with the endemic influenza season, which is now joined by COVID and, in
2026-10-23A Study of Nicotine Orodispersible Tablet on Craving Relief of Male and Female Smoker VolunteersClinical trials · Phase 2 · Recruiting · Sponsor: McNeil AB · Registry update posted 2026-10-23 · Enrollment: 280 · Primary completion: 2027-10-30The objective of the study is to evaluate the relief of momentary urge to smoke at pre-specified early post-dose time points after administration of Nic ODT compared to Placebo ODT.
2026-10-23Less Doses of Daratumumab Are Adequate to Achieve Response in Newly Diagnosed Multiple MyelomaClinical trials · Phase 2 · Recruiting · Sponsor: Tata Memorial Centre · Registry update posted 2026-10-23 · Enrollment: 52 · Primary completion: 2029-05-05The goal of this clinical trial is to evaluate whether a modified (less frequent) dosing schedule of daratumumab, when added to standard VRd therapy, can be an effective induction regimen for treating newly diagnosed multiple myeloma (NDMM).
The main questions it aims to answer
2026-10-23Exploratory Study of the Efficacy of HAL-PDT in CIN 3Clinical trials · Phase 2 · Not yet recruiting · Sponsor: Tongji Hospital · Registry update posted 2026-10-23 · Enrollment: 260 · Primary completion: 2028-06This is a prospective, multicenter, biomarker-guided Phase II study evaluating the efficacy and safety of hexaminolevulinate-mediated cervical photodynamic therapy (HAL-PDT) in women with cervical intraepithelial neoplasia grade 3 (CIN3). Approximately 260 women aged 18 to 50 yea
2026-10-23ESP Blocks in Breast Free FlapsClinical trials · Phase 1 · Recruiting · Sponsor: Carilion Clinic · Registry update posted 2026-10-23 · Enrollment: 60 · Primary completion: 2028-06-30This study is a prospective randomized controlled trial to assess the efficacy of erector spinae plane (ESP) blocks in patients undergoing autologous free flap breast reconstruction. Currently, patients undergoing this procedure remain in the hospital initially for flap monitorin
2026-10-23Epcoritamab as Consolidative Therapy for Waldenstr(SqrRoot)(Delta)m Macroglobulinemia (WM) Treated With a Bruton Tyrosine Kinase Inhibitor (BTKi)Clinical trials · Phase 2 · Not yet recruiting · Sponsor: National Heart, Lung, and Blood Institute (NHLBI) · Registry update posted 2026-10-23 · Enrollment: 24 · Primary completion: 2030-11-01Background:
Waldenstrom macroglobulinemia (WM) is a type of blood cancer. It causes the blood to get thicker, which slows circulation and makes it harder to carry oxygen and other substances around the body. WM is treated with drugs called Bruton tyrosine kinase inhibitors (BTKi
2026-10-23Effects of Switch to Doravirine/Islatravir vs. Continued Antiretroviral Therapy on Biomarkers of Aging Among Virologically Suppressed People With HIVClinical trials · Phase 2 · Not yet recruiting · Sponsor: The University of Texas Health Science Center, Houston · Registry update posted 2026-10-23 · Enrollment: 60 · Primary completion: 2028-04-15The purpose of this study is to quantify biologic aging (using validated epigenetic clocks) as downstream indicators of Long Interspersed Nuclear Element-1 (LINE-1) retrotransposon activity before and after switch to doravirine (DOR)/Islatravir (ISL) , to estimate whether effects
2026-10-23Phase 3 Study of Denifanstat in Participants With Moderate to Severe Acne (AURORA)Clinical trials · Phase 3 · Recruiting · Sponsor: Sagimet Biosciences Inc. · Registry update posted 2026-10-23 · Enrollment: 800 · Primary completion: 2027-08The purpose of this study is to evaluate the safety and efficacy of denifanstat compared with matching placebo in participants with moderate to severe acne vulgaris who are ≥12 years of age. After the 12-week treatment phase, a subset of approximately 530 participants will have t
2026-10-23Dynamic Magnetic Resonance Imaging of Human Subarachnoid Space Using Intrathecal Gadolinium ContrastClinical trials · Phase 1 · Not yet recruiting · Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) · Registry update posted 2026-10-23 · Enrollment: 15 · Primary completion: 2028-03-15Background:
Cerebrospinal fluid (CSF) is the liquid that fills the space around the brain and spinal cord. Researchers do not fully understand how CSF flows and drains around the brain. They want to test a tracer (gadobutrol)-a special dye injected into the CSF-to find out if it
2026-10-23Base-Edited Hematopoietic Stem/Progenitor Cell Gene Therapy for Treatment of CXCR4-WHIMClinical trials · Phase 1 / Phase 2 · Enrolling by invitation · Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) · Registry update posted 2026-10-23 · Enrollment: 10 · Primary completion: 2031-12-31Background:
Warts, hypogammaglobulinemia, infections and myelokathexis syndrome (WHIMs) is a rare disorder that affects the immune system. People with WHIMs can have severe infections all over their body. WHIMs is caused by a mutation in the CXCR4 gene. Treatment with drugs can
2026-10-23Phase 1 Study of CH505 HIV Vaccine Nanoparticles and mRNA Boosters in Healthy AdultsClinical trials · Phase 1 · Recruiting · Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) · Registry update posted 2026-10-23 · Enrollment: 54 · Primary completion: 2028-06-07This Phase 1 study will evaluate the safety, tolerability, and immune responses of investigational CH505 HIV vaccine regimens in adults in overall good health without HIV. Participants will receive CH505 protein nanoparticle vaccines (DV901-NP) formulated with the investigational
2026-10-23Combination Bevacizumab and PRGN-2012 in Adults With Recurrent Respiratory Papillomatosis (RRP)Clinical trials · Phase 2 · Not yet recruiting · Sponsor: National Cancer Institute (NCI) · Registry update posted 2026-10-23 · Enrollment: 50 · Primary completion: 2029-07-01Background:
Recurrent respiratory papillomatosis (RRP) is a rare disease that causes wart-like growths called papillomas to grow in the airway, most often in the voice box, windpipe, or lungs. These growths can make it hard to speak or breathe. Surgery can remove the papillomas,
2026-10-23Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump TherapyClinical trials · Phase 1 · Not yet recruiting · Sponsor: National Cancer Institute (NCI) · Registry update posted 2026-10-23 · Enrollment: 20 · Primary completion: 2029-12-31Background:
Cancers that begin in the colon, adrenal glands, or bile ducts may spread to the liver. These liver tumors are often treated using a hepatic artery infusion (HAI) pump. The HAI pump is installed in the artery that goes to the liver; drugs are administered directly to
2026-10-23A Study to Investigate Canvuparatide Compared With Placebo in Adult Patients With HypoparathyroidismClinical trials · Phase 3 · Recruiting · Sponsor: MBX Biosciences · Registry update posted 2026-10-23 · Enrollment: 160 · Primary completion: 2028-01The purpose of this study is to investigate the efficacy and safety of canvuparatide administered as a once-weekly (QW) treatment to adult study participants with hypoparathyroidism (HypoPT).
2026-10-23A Study to Investigate the Safety and Effectiveness of SAR448851 in Participants With Early Alzheimer's DiseaseClinical trials · Phase 2 · Recruiting · Sponsor: Sanofi · Registry update posted 2026-10-23 · Enrollment: 160 · Primary completion: 2029-07-31This is a randomized, placebo-controlled Phase 2 study to evaluate the efficacy and safety of SAR448851 in early Alzheimer's disease (AD) participants. The purpose of this study is to measure efficacy and safety with once daily oral SAR448851 compared to placebo in participants w
2026-10-23Safety and Tolerability of Subretinal OPGx-RDH12-1001 for LCA-Associated Inherited Retinal Degeneration (LCA-IRD)Clinical trials · Phase 1 / Phase 2 · Not yet recruiting · Sponsor: Opus Genetics, Inc · Registry update posted 2026-10-23 · Enrollment: 10 · Primary completion: 2032-12This study is an early-stage clinical trial (Phase 1b/2a) testing a gene therapy called OPGx-RDH12 for people with Leber Congenital Amaurosis (LCA) caused by mutations in the RDH12 gene, a rare genetic eye disease that leads to severe vision loss. The treatment is delivered as a
2026-10-23A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Non-Small Cell Lung CancerClinical trials · Phase 2 · Recruiting · Sponsor: Verastem, Inc. · Registry update posted 2026-10-23 · Enrollment: 105 · Primary completion: 2027-06This study will assess the safety and efficacy of VS-7375 alone and in combination with cetuximab in patients with metastatic KRAS G12D - mutated Non-Small Cell Lung Cancer
2026-10-23A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)Clinical trials · Phase 2 · Recruiting · Sponsor: Windward Bio · Registry update posted 2026-10-23 · Enrollment: 105 · Primary completion: 2027-12-17This study is trying to identify the right dose of a long-acting medicine called WIN378 for people with moderate - severe chronic obstructive pulmonary disease (COPD). WIN378 blocks the action of a protein called TSLP that causes inflammation in the lung and may contribute to COP
2026-10-23Stem Cell Transplantation for Participants With Germline RUNX1 Associated Blood CancersClinical trials · Phase 2 · Not yet recruiting · Sponsor: National Cancer Institute (NCI) · Registry update posted 2026-10-23 · Enrollment: 102 · Primary completion: 2033-06-01Background:
Some blood cancers can be caused by germline variants (changes) in a person s RUNX1 gene. Germline variants are genetic inherited changes a person is born with. Stem cell transplants are used to treat many diseases including blood cancers. Stem cell transplantation f
2026-10-23A Study of SA030 Injection in Overweight or Obese ParticipantsClinical trials · Phase 1 · Recruiting · Sponsor: Suzhou Siran Biotechnology Co.,Ltd. · Registry update posted 2026-10-23 · Enrollment: 40 · Primary completion: 2028-04-24This study is the first time SA030 is being given to people. The goal is to understand how safe it is, how well it is tolerated, and how the body processes and responds to a single dose of SA030 in individuals who are overweight or obese.
Over the last few decades, more and more
2026-10-23Phase II Neoadjuvant Study of Garsorasib Followed by Ivonescimab Plus Chemotherapy in Resectable Stage IIA-IIIB KRAS G12C-Mutant NSCLC (GIVEN Study)Clinical trials · Phase 2 · Recruiting · Sponsor: Guangdong Provincial People's Hospital · Registry update posted 2026-10-23 · Enrollment: 32 · Primary completion: 2027-12-31This study is a multicenter, prospective, open-label clinical trial. It enrolls previously untreated patients with resectable stage IB-IIIB KRAS G12C mutation-positive NSCLC to evaluate the efficacy and safety of glesorasib sequentially combined with ivonescimab and chemotherapy